How Does Stem Cell Therapy Help Parkinson’s Patients

 Parkinson's is the most common neurodegenerative condition in the world, with nearly 10 million Parkinson's patients. Parkinson's disease starts with mild symptoms, but over time, they can become so severe that it affects the patient's lifestyle, leading to depression and anxiety.

Stem cell therapy has proven to be an innovative management strategy, which improves daily functionality and quality-of-life.

This blog will briefly discuss the symptoms and typical characteristics of Parkinson's before focusing on how stem cell therapies can transform the treatment of Parkinson's in India.

Understanding Parkinson's

Parkinson’s disease affects movement, muscle control and balance. The cells of the substantia-nigra (basal ganglia) are affected. It interferes with the brain's production of dopamine (the happy-hormone). The neurons in the brain begin to deteriorate as the disease advances. This causes severe motor impairments, tremors, stiffness and a slowed down or delayed movement.

Parkinson's disease symptoms

Parkinson's disease patients can experience one or more of the following symptoms.

Tremor

Drooling

Dysphagia

Dizzy spells

Slurred speech

Standing posture

Dragging of the feet

Depression and anxiety

Spastic limb movements

Hypomimia, or the masked face

Shaking fingers, hands or lips

Uneven coordination and imbalance

Micrographia, or small handwriting

The bladder and bowels lose control

Hypophonia is a soft or unusually low voice

A feeling of numbness or weakness is felt in the extremities

Slowing down of movement (bradykinesia).

Loss of control in movements such as blinking or smiling

Standing up is difficult after a long period of sitting and vice versa

The loss of muscle control begins on one side and then spreads to the other

Dyskinesia is an uncontrollable movement, such as jerks or twitches.

Let's look at the two cases managed by Team Plexus. Dr Na'eem Sadik, India's award winning stem cell specialist, is in charge.

From depression to confidence

In 2014, a 58-year old businessman in Bangalore named Mr J began experiencing tremors, a symptom of Parkinson's. He dismissed them at first as just trembling spells. When more serious symptoms like muscle pain, stiffness and involuntary movement started to appear, Mr J began consulting several doctors. Unfortunately, the majority of doctors diagnosed Parkinson's Disease. Slowly, the condition began to control Mr J's actions and he was often unable to perform his daily tasks. In addition, Mr J's facial tremors made it difficult to speak clearly. The daily struggle with Parkinson's began to affect Mr J's ability to communicate with others, and pushed him towards depression. He visited clinic after clinic in search of a permanent cure for his Parkinson's but was disappointed by what he discovered. Plexus' multidisciplinary team and Mr J were discovered by Mr J in April 2015. We carried out a thorough investigation into his condition, and then designed a treatment plan for him. In only two months, Mr J’s symptoms lessened, his speech improved, and he gained the confidence to live on his own. Plexus' stem cell therapy helped Mr J to believe in himself by getting him back on the fast track of recovery.

A step towards good health

Mr A, 35, who works in London, was surprised when doctors told him in 2010 that the slight tremors in his left hand and his slowly decreasing walking speed were symptoms of Parkinson's. Mr A, who was 35 years old and working in London, was shocked when doctors told him that the slight tremors in his left arm and his slowly reducing walking speed were signs of Parkinson's disease. After his diagnosis, Mr A suffered from Parkinson's debilitating symptom and its side effects for seven years. At this point, Mr A had lost all hope, and was at his wits' end. He began to slide into depression. His wife's optimism, as well as her insistence that he visit various Ayurveda practitioners, homeopaths, and allopaths, kept Mr A's spirits high during this difficult time. While Mrs A was searching online for treatment options, she came across Plexus Neuro & Stem Cell Centre. The couple spoke immediately with Dr Na'eem Sadiq who convinced them to relocate to Bangalore for stem cell treatment in 2018. During the intensive two-month treatment at our centre Mr A received a holistic program which included stem cell therapy, physiotherapy, occupational therapy, and a comprehensive intervention. He was prescribed nutritional supplements to meet his diet requirements throughout his treatment. The international standards of healthcare at the Plexus centre, as well as the positive attitude and care shown by Dr Sadiq and the Plexus staff left a lasting impact on Mr A. He celebrated his rapid recovery by taking part in singing and painting contests at the centre. After his treatment, Mr A was a different man. Armed with the confidence that he is in good health, he left the centre.

Stem Cell Therapy in Parkinson's

Stem cells have the ability to differentiate into different cell types. This makes stem cells the perfect choice for regenerative medicines, particularly in neurodegenerative diseases like Parkinson's.

In order to restore normal brain function, healthy stem cells are introduced in the brain. They replace neurons that have been damaged or destroyed. This procedure has the potential to slow or stop Parkinson's progression. Plexus uses mesenchymal cells (MSCs), as part of its customized regenerative rehab program for Parkinson's. MSCs are a promising candidate to address the complex pathology associated with Parkinson's disease due to their regenerative, immunomodulatory, and anti-inflammatory properties.

Take a look at MSCs to see how they can improve the quality-of-life of patients with Parkinson's disease:

Regenerative Ability

Neuronal Differentiation

MSCs are capable of dividing into different cell types including neurons. They can replace dopamine-producing cells that have been damaged or lost once they are placed in the brain. This will slow down the progression of Parkinson's.

Production of Neurotrophic Factor

MSCs secrete factors neurotrophic that promote the growth and survival of neurons. This neuroprotective action is crucial in preventing the further degeneration dopamine-producing cell.

Antiinflammatory and Immunomodulatory effects

Reducing Neuroinflammation

In Parkinson's, neuronal injury is caused by inflammation. MSCs have anti-inflammatory properties that help modulate inflammatory responses and create an environment more conducive to neuronal survival.

Immunomodulation

MSCs can reduce the autoimmune component of Parkinson's disease by significantly reducing the immune system. They suppress harmful immune responses, and promote an environment that is anti-inflammatory.

Enhancing Neuroplasticity

Promoting synaptic connectivity

MSCs are able to enhance the synaptic connection between neurons. This is crucial for improving motor and cognition functions that are affected by Parkinson's.

Reducing motor symptoms

Improving motor function

MSCs can restore dopamine levels by differentiating to dopamine-producing cells or by promoting the survival and growth of existing neurons.

The use of stem cells to treat Parkinson's represents a new paradigm in treating this condition. Stem cell therapy has become a popular treatment for chronic diseases due to its ability to provide relief and avoid the side effects and pain of surgery. Plexus is always working to bring this modern miracle to those who most need it.

Team Plexus can provide you with more information about stem cell treatment for Parkinson's disease. Contact them today.

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+91 82299 99888 (Bangalore)