Exploring the Link Between Vitamin D and Multiple Sclerosis - Plexus
Multiple Sclerosis (MS) is an autoimmune, neurodegenerative
and inflammatory condition that attacks
the central nervous system (CNS). It corrupts the immune system, making it work
against the body.
Although there are various
factors contributing to the development and progression of MS, including
genetic predisposition, environmental factors, and immune dysregulation, it is
the role of vitamin D that has garnered significant attention in recent years.
This may be due to its potential influence on both MS risk and disease
activity. Through this comprehensive blog, we will throw light on the connection
between vitamin D and multiple sclerosis, as well as examine the evidence
supporting the former’s role in the development and progression of the disease.
What is Vitamin D?
Vitamin D is a fat-soluble
vitamin that plays a crucial role in various physiological processes, including
bone health, immune function, and regulation of calcium and phosphorus
metabolism. There are two primary forms of vitamin D: vitamin D2 (ergocalciferol)
and vitamin D3 (cholecalciferol). Vitamin D2 is synthesized by plants, while
vitamin D3 is produced in the skin upon exposure to ultraviolet B (UVB)
sunlight and is also found in some animal-based foods.
Sources of Vitamin D
The following are the main
sources of vitamin D:
Sunlight: The primary source of vitamin D is
sunlight exposure, which triggers the synthesis of vitamin D3 in the skin.
Spending time outdoors during peak sunlight hours can help maintain adequate
vitamin D levels.
Dietary sources: Vitamin D can also be obtained through
dietary sources, including fatty fish (such as salmon, mackerel, and tuna), egg
yolks, fortified dairy products (such as milk and yogurt), fortified cereals,
and some fortified plant-based milk alternatives.
In cases where adequate sun exposure and
dietary intake are insufficient to meet vitamin D requirements, supplementation
with vitamin D supplements may be prescribed by doctors.
Who is at Risk of Vitamin D
Deficiency?
There are several factors
that can increase the potential risk of vitamin D deficiency. These include:
● Limited sunlight exposure
● Darker skin pigmentation
● Age
● Limited dietary intake
● Obesity
● Existing medical conditions that impact
fat absorption (celiac disease, Crohn's disease, and cystic fibrosis)
● Liver or kidney disease
● Certain medications (corticosteroids and
anticonvulsants)
Vitamin D and Multiple Sclerosis:
At First Glance
Vitamin D is often referred
to as the "sunshine vitamin.” It plays a critical role in calcium
metabolism, immune regulation, as well as overall health. Primarily, it is
synthesized in the skin post exposure to sunlight. Additionally, vitamin D may
also be obtained through dietary sources and supplements.
In the past few years,
epidemiological studies have provided compelling evidence corroborating the
link between vitamin D and MS risk. The prevalence of MS is higher in
populations living at higher latitudes, where sunlight exposure is limited, as
compared to those residing closer to the equator. Moreover, individuals with MS
have even been known to exhibit lower vitamin D levels compared to healthy
controls. This further cements the potential protective effect of vitamin D
against the development of MS.
The optimal vitamin D level
in the blood can vary based on individual factors and health conditions.
However, doctors recommend aiming for a blood level of 25-hydroxyvitamin D,
also known as 25(OH)D, between 30 to 50 ng/mL (nanograms per milliliter) for general
health and disease prevention. For MS patients, maintaining vitamin D levels in
the range of 40 to 60 ng/mL (nanograms per milliliter) of 25-hydroxyvitamin D
(25(OH)D) in the blood is beneficial.
It is important to keep in
mind that the optimum vitamin D for an individual must be based on factors such
as age, overall health status, and existing medical conditions.
How Does a Vitamin D Deficiency
Lead to Multiple Sclerosis?
There are several
multifaceted mechanisms underlying the relationship between vitamin D
deficiency and multiple sclerosis. These factors include inflammation
regulation, immune modulation, and neuroprotection.
Vitamin D is particularly
important for its effects on the immune system through various pathways. It
helps modulate T-cell function, promote regulatory T-cell activity, and
suppress or inhibit pro-inflammatory cytokines. Studies have shown vitamin D
can also enhance remyelination and repair processes in the CNS. This is a
critical mechanism when it comes to mitigating the neurological damage that
accompanies MS.
Vitamin D Supplementation in
Multiple Sclerosis
Individuals with lower
vitamin D levels at the time of MS diagnosis are at risk of more frequent
relapses, higher disability progression, and increased disease activity.
This is why Vitamin D
supplements may be prescribed to help lower relapse rates as well as enhance
treatment response in MS patients. However, vitamin D supplements cannot be
prescribed to everyone. There are certain eligibility criteria that need to be met.
Let’s take a look at these.
Vitamin D Supplementation Eligibility
Although vitamin D
supplementation is generally safe and beneficial for most of us, there are
certain populations who may not be eligible for supplementation, and some who
may require careful monitoring:
● Individuals with hypercalcemia (elevated
blood calcium levels)
● Individuals with conditions predisposing
them to hypercalcemia (primary hyperparathyroidism or certain types of cancer)
● Individuals with hypervitaminosis D
(elevated levels of vitamin D in their blood) (hypervitaminosis D)
Please do not start on any dietary
supplement without consulting your doctor.
How Can Individuals With MS
Improve Their Vitamin D Levels?
Here are some tips to help
MS patients increase their vitamin D levels:
Sunlight Exposure
Moderate sun exposure can
stimulate vitamin D synthesis in the skin. Even 10-30 minutes of sunlight
exposure to arms, legs, and face a few times per week can be extremely
beneficial. Exposure to sunlight particularly during midday when UVB rays are
most intense.
While sunlight is a natural source of
vitamin D, it's important to practice sun safety to prevent skin damage and
reduce the risk of skin cancer. Use sunscreen, wear protective clothing, and
avoid prolonged sun exposure during peak hours.
Dietary Sources
Nutrient-dense foods that
are rich in vitamin D are important. Some examples include fatty fish (salmon,
mackerel, tuna), egg yolks, milk, yogurt, paneer (fortified dairy products),
and fortified plant-based milk alternatives.
Supplementation
Begin vitamin D
supplementation under the guidance of your doctor. It's essential to have
levels monitored regularly to avoid toxicity, the symptoms of which includeL
● Nausea
● Vomiting
● Weakness
● Fatigue
● Loss of appetite
● Constipation
● Excessive thirst
● Frequent urination
● Muscle weakness
● Kidney stones
● Confusion
● Disorientation
Lifestyle Modifications
Regular exercise, stress
management techniques, getting adequate sleep, quitting smoking,
limiting/quitting alcohol intake can significantly help support overall health
and well-being.
The relationship between vitamin
D and multiple sclerosis is complex and multifaceted. Optimizing vitamin D
status through requisite supplementation and lifestyle interventions can help
mitigate MS risk and contribute towards slowing down disease progression.
However, just vitamin D supplementation cannot be the sole treatment for MS. It
should be viewed as part of a comprehensive approach to MS management.
Regenerative Rehabilitation for
Multiple Sclerosis at Plexus
Stem cell therapy using mesenchymal stem cells (MSCs) is an innovative approach to managing MS,
providing long-term relief, and even addressing its underlying causes. MSCs,
derived from various tissues such as bone marrow and adipose tissue, have shown
immunomodulatory properties, making them a potential therapeutic tool for
disorders like MS.
At Plexus, our customized regenerative
rehabilitation program for multiple sclerosis provides relief from symptoms, slows down
disease progression, and improves quality of life.
Below are the features of
MSCs that aid in managing MS:
● MSCs secrete anti-inflammatory molecules
that can potentially reduce inflammation in the affected tissues. This can help
mitigate the destructive impact of autoimmune responses.
● MSCs can modulate the immune system by
suppressing the activity of hyperactive immune cells and promoting regulatory
T-cell function. They have the ability to create a more balanced and controlled
immune response.
● MSCs can repair or regenerate damaged
tissues, and contribute to the repair of myelin and nerve fibers, potentially
slowing down (and even reverse in some cases) some of the neurological damage
associated with the disease.
Our comprehensive rehabilitation for
multiple sclerosis also includes:
● Motor relearning program
●
Gait
training
●
Functional
strengthening
●
Coordination
training
●
Speech
therapy
● Nutritive therapies and more
If you wish to know more
about our award-winning rehabilitation program for
Multiple Sclerosis,
reach out to our team in Bangalore or Hyderabad today.
WhatsApp +91 89048 42087
Call +91 78159 64668 (Hyderabad) | +91 82299 99888 (Bangalore)
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